Aplysinadiene and (R,R)-5-[[3,5-dibromo-4-[(2-oxo-5-oxazolidinyl)]methoxy]phenyl]-2-oxazolidinone, two novel metabolites from Aplysina aerophoba. Synthesis of aplysinadiene was written by Norte, M.;Rodriguez, M. L.;Fernandez, J. J.;Eguren, L.;Estrada, D. M.. And the article was included in Tetrahedron in 1988.Reference of 108940-96-1 This article mentions the following:
Two novel constituents, biogenetically derived from dibromotyrosine, were obtained from a sponge Aplysina闁?em>aerophoba. The structure of aplysinadiene (I) was established on the basis of its spectral properties and by synthesis of I and its isomers (1′E)- and (1′Z)-II. The structure and absolute configuration of the oxazolidinone III was established by x-ray diffraction anal. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Reference of 108940-96-1).
3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon闁艰京鐗梤omine bond is electrophilic in nature. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Reference of 108940-96-1
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary