Month: February 2023

Polyamide-Scorpion cyclam lexitropsins selectively bind AT-rich DNA independently of the nature of the coordinated metal was written by Lo, Anthony T. S.;Salam, Noeris K.;Hibbs, David E.;Rutledge, Peter J.;Todd, Matthew H.. And the article was included in PLoS One in 2011.HPLC of Formula: 1196-90-3 This article mentions the following:

Cyclam was attached to 1-, 2- and 3-pyrrole lexitropsins for the first time through a synthetically facile copper-catalyzed “click” reaction. The corresponding copper and zinc complexes were synthesized and characterized. The ligand and its complexes bound AT-rich DNA selectively over GC-rich DNA, and the thermodn. profile of the binding was evaluated by isothermal titration calorimetry. The metal, encapsulated in a scorpion azamacrocyclic complex, did not affect the binding, which was dominated by the organic tail. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-1-methyl-1H-pyrrole-2-carboxylate (cas: 1196-90-3HPLC of Formula: 1196-90-3).

Methyl 4-bromo-1-methyl-1H-pyrrole-2-carboxylate (cas: 1196-90-3) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.HPLC of Formula: 1196-90-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Double C(sp³)-H Bond Functionalization Mediated by Sequential Hydride Shift/Cyclization Process: Diastereoselective Construction of Polyheterocycles was written by Mori, Keiji;Kurihara, Kazuki;Yabe, Shinnosuke;Yamanaka, Masahiro;Akiyama, Takahiko. And the article was included in Journal of the American Chemical Society in 2014.Reference of 61150-57-0 This article mentions the following:

Described herein are two novel types of double C(sp³)-H bond functionalizations triggered by a sequential hydride shift/cyclization process: (1) construction of a bicyclo[3.2.2]nonane skeleton, e.g., I, by a [1,6]- and [1,5]-hydride shift sequence and (2) sequential [1,4]- and [1,5]-hydride shift mediated construction of a linear tricyclic skeleton, e.g., II. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Reference of 61150-57-0).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Reference of 61150-57-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Design, synthesis, and in vitro evaluation of an activity-based protein profiling (ABPP) probe targeting agmatine deiminases was written by Thomson, Andrew;O’Connor, Sean;Knuckley, Bryan;Causey, Corey P.. And the article was included in Bioorganic & Medicinal Chemistry in 2014.Related Products of 954-81-4 This article mentions the following:

Agmatine deiminases (AgDs) belong to a family of enzymes known as guanidinium group modifying enzymes (GMEs). Many pathogenic bacteria encode an AgD that participates in the catabolism of agmatine (decarboxylated arginine). This catabolism may confer a competitive survival advantage, by virtue of energy production and increased acid tolerance, making this sub-family of enzymes a potential therapeutic target that warrants further study. Herein we report the development of an activity-based protein profiling (ABPP) probe that selectively targets the AgD from Streptococcus mutans. Due to the selectivity and covalent nature of the modification, this probe could prove to be a valuable tool for the study of other AgD family members. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Related Products of 954-81-4).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon闁艰京鐗梤omine bond is electrophilic in nature. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Related Products of 954-81-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A Potent and Highly Selective Inhibitor of Human 濞?1,3-Fucosyltransferase via Click Chemistry was written by Lee, Lac V.;Mitchell, Michael L.;Huang, Shih-Jung;Fokin, Valery V.;Sharpless, K. Barry;Wong, Chi-Huey. And the article was included in Journal of the American Chemical Society in 2003.Name: N-(5-Bromopentyl)phthalimide This article mentions the following:

Potent inhibitors of fucosyltransferases, and glycosyltransferases in general, have been elusive due to the inherent barriers surrounding the family of glycosyl transfer reactions. The problems of weak substrate affinity and low catalytic proficiency of fucosyltransferase was offset by recruiting addnl. binding features, in this case hydrophobic interactions, to produce a high affinity inhibitor, 24, with K_i = 62 nM. The mol. was identified from a GDP-triazole library of 85 compounds, which was produced by the Cu(I)-catalyzed [2+3] cycloaddition reaction between azide and acetylene reactants, followed by in situ screening without product isolation. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Name: N-(5-Bromopentyl)phthalimide).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Name: N-(5-Bromopentyl)phthalimide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of (5’S)-5′-C-alkyl-2′-deoxynucleosides was written by Trafelet, Huldreich;Stulz, Eugen;Leumann, Christian. And the article was included in Helvetica Chimica Acta in 2001.Recommanded Product: Isopentyltriphenylphosphonium bromide This article mentions the following:

We describe the synthesis of (5’S)-5′-C-butylthymidine, of the (5’S)-5′-C-butyl- and the (5’S)-5′-C-isopentyl derivatives of 2′-deoxy-5-methylcytidine, as well as of the corresponding cyanoethyl phosphoramidites resp. Starting from thymidin-5′-al, the alkyl chain at C(5′) is introduced via Wittig chem. to selectively yield the (Z)-olefin derivatives The secondary OH function at C(5′) is then introduced by epoxidation followed by regioselective reduction of the epoxy derivatives 4a and 4b with diisobutylaluminium hydride. In the latter step, a kinetic resolution of the diastereoisomer mixture occurs, yielding the alkylated nucleoside, with (5’S)-configuration in high diastereoisomer purity (de = 94%). The corresponding 2′-deoxy-5-methylcytidine derivatives are obtained from the protected 5′-alkylated thymidine derivatives via known base interconversion processes in excellent yields. Application of the same strategy to the purine nucleoside 2′-deoxyadenine to obtain 5′-C-butyl-2′-deoxyadenosine 25 proved to be difficult due to the sensitivity of the purine base to hydride-based reducing agents. In the experiment, the researchers used many compounds, for example, Isopentyltriphenylphosphonium bromide (cas: 28322-40-9Recommanded Product: Isopentyltriphenylphosphonium bromide).

Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Recommanded Product: Isopentyltriphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Physicochemical properties and membrane interactions of per(6-desoxy-6-halogenated) cyclodextrins was written by Debouzy, J.-C.;Crouzier, D.;Gadelle, A.. And the article was included in Annales Pharmaceutiques Francaises in 2007.Quality Control of Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin This article mentions the following:

Per(6-iodo-6-desoxy) cyclodextrins are synthesis intermediates used in the design of the cation chelating per(3,6-anhydro) cyclodextrins. The modifications of the properties of these mols. resulting from the nature of the halogen substituent and also the number of osidic building blocks were investigated by varying both factors, using ¹H and ³¹P-NMR and EPR spectroscopies. These nearly water insoluble mols. exhibits no complexing properties (for both ionic and apolar structures) but can be partially solubilized in micelles of detergent (SDS) and also in phospholipid vesicles. Dipolar connectivity (nOesy) NMR experiments show that they are embedded at the chain level of the micelles/vesicles, without any inclusion complex formation. Changing the number of glucose building blocks (6,7 or 8) or/and the nature of the halogen nuclei at the positions 6 strongly modify cyclodextrin affinities and membrane interactions. For instance the per(6-bromo-6-desoxy)-cyclomaltohexaose (ABR) and -cyclomalto-heptaose (BBR) exhibit a selective affinity for cobalt (apparent K_a of 2500 and 790 M^-1, resp.). In terms of interactions with membranes, 濞?derivatives induce sterical hindrance at the phosphorus level while destructuring the chains. Other derivatives are located deeper and rigidify the most superficial part of the chain, suppressing the jump in membrane fluidity at transition temperature In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin (cas: 53784-83-1Quality Control of Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin).

Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Quality Control of Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Regio- and Stereoselective Alkylboration of Endocyclic Olefins Enabled by Nickel Catalysis was written by Ding, Chao;Ren, Yaoyu;Sun, Caocao;Long, Jiao;Yin, Guoyin. And the article was included in Journal of the American Chemical Society in 2021.Related Products of 57293-19-3 This article mentions the following:

Whereas there is a significant interest in the rapid construction of diversely substituted saturated heterocycles, direct and modular access is currently limited to the mono-, 2,3-, or 3,4-substitution pattern. This Communication describes the straightforward and modular construction of 2,4-substituted saturated heterocycles from readily available materials in a highly stereo- and regioselective manner, which sets the stage for numerous readily accessible drug motifs. The strategy relies on chain walking catalysis. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Related Products of 57293-19-3).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Related Products of 57293-19-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Design, synthesis and evaluation of N13-substituted evodiamine derivatives against human cancer cell lines was written by Song, Senchuan;Chen, Zhiyong;Li, Shaoxue;Huang, Yanmin;Wan, Yiqian;Song, Huacan. And the article was included in Molecules in 2013.Name: 1-Bromo-4-methoxybutane This article mentions the following:

Attempting to improve the anticancer activity and solubility of evodiamine in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) solutions, thirty-eight N13-substituted evodiamine derivatives were designed, synthesized and tested for antitumor activity against six kinds of human cancer cell lines, namely prostate cancer (DU-145 and PC-3), lung cancer (H460), breast cancer (MCF-7), colon cancer (HCT-5) and glioblastoma (SF-268). The solubility of these compounds in SGF and SIF solutions was evaluated and apoptosis induced the title compounds was determined The results showed that among all compounds examined, several showed the highest antitumor activity and a broader spectrum of activity, with IC50 values ranging from 1-2 婵炴挾鎷? Their solubility was obviously improved and several compounds had a significant impact inducing apoptosis in some cancer cell lines. The preliminary structure-activity relationships of these derivatives were discussed. The synthesis of the target compounds was achieved by alkylation of (13bS)-8,13,13b,14-tetrahydro-14-(methyl)indolo[2′,3′:3,4]pyrido[2,1-b]quinazolin-5(7H)-one (evodiamine) with alkylation agents, such as alkyl bromides. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Name: 1-Bromo-4-methoxybutane).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Name: 1-Bromo-4-methoxybutane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chemoselectivity in the Kosugi-Migita-Stille coupling of bromophenyl triflates and bromo-nitrophenyl triflates with (ethenyl)tributyltin was written by Ansari, Nurul N.;Cummings, Matthew M.;Soderberg, Bjorn C. G.. And the article was included in Tetrahedron in 2018.Reference of 76361-99-4 This article mentions the following:

Kosugi-Migita-Stille cross coupling reactions of (ethenyl)tributyltin with all isomeric permutations of bromophenyl triflate and bromo-nitrophenyl triflate were examined in order to determine the chemoselectivity of carbon-bromine vs. carbon-triflate bond coupling under different reaction conditions. In general, highly selective carbon-bromine bond cross couplings were observed for example bis(triphenylphosphine)palladium dichloride (2 mol %) in 1,4-dioxane at reflux. In contrast, reactions using the same pre-catalyst but in the presence of a three-fold excess of lithium chloride in N,N-dimethylformamide at ambient temperature were in most cases selective for coupling at the carbon-triflate bond. Overall, isolated yields and the selectivity for carbon-bromine bond coupling were significantly higher compared to carbon-triflate bond coupling. In the experiment, the researchers used many compounds, for example, 3-Bromo-2-nitrophenol (cas: 76361-99-4Reference of 76361-99-4).

3-Bromo-2-nitrophenol (cas: 76361-99-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Reference of 76361-99-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Selective synthesis of mono- and di-methylated amines using methanol and sodium azide as C1 and N1 sources was written by Chakrabarti, Kaushik;Mishra, Anju;Panja, Dibyajyoti;Paul, Bhaskar;Kundu, Sabuj. And the article was included in Green Chemistry in 2018.Safety of 2-Bromo-1,10-phenanthroline This article mentions the following:

A Ru(II) complex mediated synthesis of various N,N-di-Me and N-monomethyl amines from organic azides using methanol as a methylating agent was reported. This methodol. was successfully applied for a one-pot reaction of bromide derivatives and sodium azide in methanol. Notably, by controlling the reaction time several N-monomethylated and N,N-dimethylated amines were synthesized selectively. The practical applicability of this tandem process was revealed by preparative scale reactions with different organic azides and synthesis of an anti-vertigo drug betahistine. Several kinetic experiments and DFT studies were carried out to understand the mechanism of this transformation. In the experiment, the researchers used many compounds, for example, 2-Bromo-1,10-phenanthroline (cas: 22426-14-8Safety of 2-Bromo-1,10-phenanthroline).

2-Bromo-1,10-phenanthroline (cas: 22426-14-8) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon闁艰京鐗梤omine bond is electrophilic in nature. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Safety of 2-Bromo-1,10-phenanthroline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary