Month: February 2023

Novel metal complexes of pyridineimine derivative used as auxiliary electron acceptor of D-(A-π-A)₂ motif dye sensitizer: synthesis and photovoltaic application was written by Tian, Yong;Wang, Kaixuan;Wu, Xianming;Tang, Shiyu;Zhang, Houpeng;Zhong, Chaofan. And the article was included in Journal of Solid State Electrochemistry in 2022.Quality Control of 1-Bromopyrrolidine-2,5-dione This article mentions the following:

The auxiliary acceptors of metal complexes can easily regulate the electron-withdrawing ability of electron acceptor and adjust the balance of push-pull electron of D-A-π-A motif dye sensitizers. Two series of the D-(A-π-A)₂ motif dye sensitizer (BDTT-i.m.-Co, BDTT-i.m.-Cu, BDTT-i.m.-Zn, BDTT-i.m.-Cd and FL-i.m.-Co, FL-i.m.-Cu, FL-i.m.-Zn, FL-i.m.-Cd) which use metal complexes of pyridineimine derivative as auxiliary acceptor were designed, synthesized, and characterized. The photovoltaic test of eight complex-based dye sensitized solar cells (DSSCs) showed that the short-circuit photocurrent d. (J_SC) and the power conversion efficiency (PCE) of two series dye sensitizers are sequentially increased. BDTT-i.m.-Cd have the highest J_SC of 15.58 mA cm^-2 and the PCE of 9.13% under AM 1.5 irradiation, which may be due to that electron-withdrawing ability of the auxiliary acceptor metal complexes of pyridineimine derivative can be changed by the strength of coordination bond of the complexes. They also show good terminal stability with decomposition temperatures (T_d) higher than 300 °C. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Quality Control of 1-Bromopyrrolidine-2,5-dione).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Quality Control of 1-Bromopyrrolidine-2,5-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Efficient synthesis of alkylboronic esters via magnetically recoverable copper nanoparticle-catalyzed borylation of alkyl chlorides and bromides was written by Shegavi, Mahadev L.;Agarwal, Abhishek;Bose, Shubhankar Kumar. And the article was included in Green Chemistry in 2020.Recommanded Product: 57293-19-3 This article mentions the following:

We report a magnetically separable Cu nanocatalyst (Fe-DOPA-Cu) for the borylation of alkyl halides with alkoxy diboron reagents, providing alkylboronic esters in high yields, with broad functional group tolerance under mild reaction conditions. The procedure is also applicable to the borylation of benzyl chlorides and bromides. Radical clock experiments support a radical-mediated process. Easy recycling of the catalyst resulted in no significant loss of activity up to ten runs. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Recommanded Product: 57293-19-3).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Recommanded Product: 57293-19-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Comparative Molecular Moment Analysis (CoMMA): 3D-QSAR without Molecular Superposition was written by Silverman, B. D.;Platt, Daniel. E.. And the article was included in Journal of Medicinal Chemistry in 1996.Safety of 3-(Bromomethyl)benzoic acid This article mentions the following:

3D-QSAR procedures utilize descriptors that characterize mol. shape and charge distributions responsible for the steric and electrostatic nonbonding interactions intimately involved in ligand-receptor binding. Comparative mol. moment anal. (CoMMA) utilizes moments of the mol. mass and charge distributions up to and including second order in the development of mol. similarity descriptors. As a consequence, two Cartesian reference frames are then defined with respect to each mol. structure. One frame is the principal inertial axes calculated with respect to the center-of-mass. For neutrally charged mol. species, the other reference frame is the principal quadrupolar axes calculated with respect to the mol. “center-of-dipole”. QSAR descriptors include quantities that characterize shape and charge independently as well as quantities that characterize their relationship. 3D-QSAR partial least squares (PLS) cross-validation procedures are utilized to predict the activity of several training sets of mols. previously investigated. This is the first time that mol. electrostatic quadrupolar moments have been utilized in a 3D-QSAR anal., and it is shown that descriptors involving the quadrupolar moments and related quantities are required for the significant cross-validated predictive r²‘s obtained. CoMMA requires no superposition step, i.e., no step requiring a comparison between two mols. at any stage of the 3D-QSAR calculation In the experiment, the researchers used many compounds, for example, 3-(Bromomethyl)benzoic acid (cas: 6515-58-8Safety of 3-(Bromomethyl)benzoic acid).

3-(Bromomethyl)benzoic acid (cas: 6515-58-8) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Safety of 3-(Bromomethyl)benzoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Improved resistive switching WORM memory behavior in D-π-A architectures by modifying the terminal donor units was written by Harshini, Deivendran;Angela, Varghese Maria;Devibala, Paneerselvam;Imran, Predhanekar Mohamed;Bhuvanesh, Nattamai S. P.;Nagarajan, Samuthira. And the article was included in ACS Applied Electronic Materials in 2022.Recommanded Product: 128-08-5 This article mentions the following:

A series of D-π-A, D-π-D, and A-π-A based push-pull compounds with triarylamine and benzophenone were designed and synthesized for nonvolatile memory applications. All of the compounds showed good solubility in common organic solvents, which permits solution processability. D-π-A based compounds exhibited write-once-read-many (WORM) memory applications, and the compound with a methoxyphenyl substituent exhibited switching with a low threshold voltage of -0.82 V, an ON/OFF current ratio of 10², and a long-lasting retention time of 10³ s. The effect of differently functionalized triarylamines on memory behavior was explored by optical, electrochem., and computational studies. The highest HOMO levels of around 5̃.0 eV and irreversible anodic peaks (0.7-1.3 V) obtained for the compounds facilitate charge injection and switching behavior. Besides, electrochem. and d. functional theory studies disclose the charge-transfer mechanism of the D-π-A systems, which is related to the bistability of the devices. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Recommanded Product: 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Recommanded Product: 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A Fluorescent Sensor for GABA and Synthetic GABA_B Receptor Ligands was written by Masharina, Anastasiya;Reymond, Luc;Maurel, Damien;Umezawa, Keitaro;Johnsson, Kai. And the article was included in Journal of the American Chemical Society in 2012.Quality Control of N-(5-Bromopentyl)phthalimide This article mentions the following:

While γ-aminobutyric acid (GABA) is the main inhibitory neurotransmitter, suitable tools to measure its concentration in living cells with high spatiotemporal resolution are missing. Herein, the authors describe the first ratiometric fluorescent sensor for GABA, dubbed GABA-Snifit, which senses GABA with high specificity and spatiotemporal resolution on the surface of living mammalian cells. GABA-Snifit is a semisynthetic fusion protein containing the GABA_B receptor, SNAP- and CLIP-tag, a synthetic fluorophore and a fluorescent GABA_B receptor antagonist. When assembled on cell surfaces, GABA-Snifit displays a GABA-dependent fluorescence emission spectrum in the range of 500-700 nm that permits sensing micromolar to millimolar GABA concentrations The ratiometric change of the sensor on living cells is 1.8. Furthermore, GABA-Snifit can be utilized to quantify the relative binding affinities of GABA_B receptor agonists, antagonists and the effect of allosteric modulators. These properties make GABA-Snifit a valuable tool to investigate the role of GABA and GABA_B in biol. systems. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Quality Control of N-(5-Bromopentyl)phthalimide).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Quality Control of N-(5-Bromopentyl)phthalimide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Surface-initiated atom-transfer radical polymerization (SI-ATRP) of bactericidal polymer brushes on poly(lactic acid) surfaces was written by Kalelkar, Pranav P.;Geng, Zhishuai;Cox, Bronson;Finn, M. G.;Collard, David M.. And the article was included in Colloids and Surfaces, B: Biointerfaces in 2022.COA of Formula: C4H4BrNO2 This article mentions the following:

We have modified the surface of poly(lactic acid) (PLA) by bromination in the presence of N-bromosuccinimide (NBS) under UV irradiation This new approach to impart functionality to the surface does not effect the bulk of the material. Brominated PLA surfaces served as initiators for atom-transfer radical polymerization (SI-ATRP) of 2-(methacryloyloxy)ethyl trimethylammonium chloride, a quaternary ammonium methacrylate (QMA). Grafting of poly(QMA) brushes rendered PLA films hydrophilic and these films displayed a three-order of magnitude increase in antimicrobial efficacy against Gram-neg. bacteria such as Escherichia coli as compared to unmodified PLA. The two-step strategy described here to modify PLA surface represents a useful route to modified PLA materials for biomedical and antimicrobial packaging applications. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5COA of Formula: C4H4BrNO2).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.COA of Formula: C4H4BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Molecular recognition between a water-soluble organometallic complex and a β-cyclodextrin: First example of second-sphere coordination adducts possessing a catalytic activity was written by Caron, Laurent;Bricout, Herve;Tilloy, Sebastien;Ponchel, Anne;Landy, David;Fourmentin, Sophie;Monflier, Eric. And the article was included in Advanced Synthesis & Catalysis in 2004.Safety of 4-Bromo-4′-tert-butylbiphenyl This article mentions the following:

Formation of stable second-sphere adducts between a water-soluble organometallic complex and a cyclodextrin (CD) is possible by finely designing the structure of the water-soluble phosphane. The key point to obtain such adducts was the synthesis of a water-soluble phosphane which possesses a tert-butylphenyl group recognized by the CD and separated from the phosphorus atom by a Ph ring to avoid phosphane decoordination during the mol. recognition process between the organometallic complex and the CD. These adducts are able to catalyze the cleavage of water-insoluble carbonate in a biphasic system. In the experiment, the researchers used many compounds, for example, 4-Bromo-4′-tert-butylbiphenyl (cas: 162258-89-1Safety of 4-Bromo-4′-tert-butylbiphenyl).

4-Bromo-4′-tert-butylbiphenyl (cas: 162258-89-1) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Safety of 4-Bromo-4′-tert-butylbiphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Porphyrin sensitizers containing an auxiliary benzotriazole acceptor for dye-sensitized solar cells: Effects of steric hindrance and cosensitization was written by Song, Heli;Tang, Weiqiang;Zhao, Shuangliang;Liu, Qingyun;Xie, Yongshu. And the article was included in Dyes and Pigments in 2018.SDS of cas: 100189-84-2 This article mentions the following:

Dye-sensitized solar cells (DSSCs) have attracted intensive attention in developing photovoltaic devices for employing solar energy. For developing panchromatic and efficient porphyrin sensitizers, it has been demonstrated to be an effective approach to introduce an electron-withdrawing benzothiadiazole unit as an extra electron acceptor. In contrast, the structurally similar benzotriazole moiety remains relatively unknown in this respect. In this work, we have synthesized a novel porphyrin dye containing an extra electron acceptor of benzotriazole. Photophys. and electrochem. investigations revealed red-shifted absorption and a narrower band gap induced by the benzotriazole unit. Thus, a reasonable efficiency of 8.39% has been achieved with a J_sc of 17.00mAcm^-2 and a V_oc of 712mV. On this basis, to investigate the effect of the dihedral angle between the benzotriazole and the adjacent phenylene ring, one or two Me groups were attached to the ortho-positions of the phenylene ring. As a result, the enlarged torsion angles induce poor electronic coupling between the LUMO of the dyes and TiO₂, resulting in lower efficiencies of 6.61% and 3.62%, resp. With the purpose to further improve the efficiencies, coadsorption and cosensitization approaches were employed. And the efficiencies have been successfully elevated to 9.32%, 8.49% and 7.34%, resp. These results demonstrate the effectiveness of incorporating an auxiliary benzotriazole acceptor into porphyrin dyes on achieving extended light-harvesting wavelength ranges and illustrate the importance of avoiding severe torsion within the acceptor part of the porphyrin dyes. In contrast to the commonly used cosensitizers with absorption peaks lying in the absorption valley between the Soret band and the Q bands of porphyrin dyes (500-600nm), the utilization of an organic dye with broad absorption in this work has been demonstrated to be effective for improving the efficiencies despite the fact that its absorption peak at 450nm largely overlaps with the Soret band of the porphyrin dyes. These results provide an alternative approach for developing cosensitizers for porphyrin dyes. In the experiment, the researchers used many compounds, for example, 2,5-Dibromo-1,3-dimethylbenzene (cas: 100189-84-2SDS of cas: 100189-84-2).

2,5-Dibromo-1,3-dimethylbenzene (cas: 100189-84-2) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.SDS of cas: 100189-84-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

ZYH005, a novel DNA intercalator, overcomes all-trans retinoic acid resistance in acute promyelocytic leukemia was written by Tong, Qingyi;You, Huijuan;Chen, Xintao;Wang, Kongchao;Sun, Weiguang;Pei, Yufeng;Zhao, Xiaodan;Yuan, Ming;Zhu, Hucheng;Luo, Zengwei;Zhang, Yonghui. And the article was included in Nucleic Acids Research in 2018.Related Products of 14425-64-0 This article mentions the following:

Despite All-trans retinoic acid (ATRA) has transformed acute promyelocytic leukemia (APL) from the most fatal to the most curable hematol. cancer, there remains a clin. challenge that many high-risk APL patients who fail to achieve a complete mol. remission or relapse and become resistant to ATRA. Herein, we report that 5-(4-methoxyphenethyl)-[1, 3] dioxolo [4, 5- j] phenanthridin-6(5H)-one (ZYH005) exhibits specific anticancer effects on APL and ATRA-resistant APL in vitro and vivo, while shows negligible cytotoxic effect on non-cancerous cell lines and peripheral blood mononuclear cells from healthy donors. Using single-mol. magnetic tweezers and mol. docking, we demonstrate that ZYH005 is a DNA intercalator. Further mechanistic studies show that ZYH005 triggers DNA damage, and caspase-dependent degradation of the PML-RARa fusion protein. As a result, APL and ATRA-resistant APL cells underwent apoptosis upon ZYH005 treatment and this apoptosis-inducing effect is even stronger than that of arsenic trioxide and anticancer agents including 5-fluorouracil, cisplatin and doxorubicin. Moreover, ZYH005 represses leukemia development in vivo and prolongs the survival of both APL and ATRA-resistant APL mice. To our knowledge, ZYH005 is the first synthetic phenanthridinone derivative, which functions as a DNA intercalator and can serve as a potential candidate drug for APL, particularly for ATRA-resistant APL. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Related Products of 14425-64-0).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Related Products of 14425-64-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Copper-Catalyzed Cross-Coupling Reaction of Organoboron Compounds with Primary Alkyl Halides and Pseudohalides was written by Yang, Chu-Ting;Zhang, Zhen-Qi;Liu, Yu-Chen;Liu, Lei. And the article was included in Angewandte Chemie, International Edition in 2011.Category: bromides-buliding-blocks This article mentions the following:

A copper-catalyzed cross-coupling of non-activated alkyl electrophiles with organoboron compounds has been developed. The use of LiOtBu as a base was found to be crucial to the reaction. The reaction is applicable to alkyl iodides, bromides, tosylates, mesylates, and even chlorides, and tolerates many more functional groups than the previously described copper-catalyzed coupling of Grignard reagents. It provides practically useful reactivities and may thus compliment palladium and nickel-catalyzed Suzuki-Miyaura coupling reactions of alkyl halides. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Category: bromides-buliding-blocks).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary