Month: February 2023

Preparation of aromatic sulfonyl halides was written by Jenkins, F. E.;Hambly, A. N.. And the article was included in Australian Journal of Chemistry in 1953.Recommanded Product: 454-65-9 This article mentions the following:

The following RC₆H₄SO₂Cl are prepared by chlorination of the RSO₂H, which are obtained by the modified Gattermann procedure (addition of the diazonium sulfate of the appropriate amine to a suspension of Cu powder in dilute H₂SO₄ saturated with SO₂) (R, % yield given): m-Me, 50, b_0.3 77-8° (sulfonamide, m. 108.5-9.5°); ο-MeO, 51; m-Cl, 50; m-Br, 54. Refluxing the RC₆H₄SO₂Cl with excess of a saturated aqueous solution of KF gave RC₆H₄SO₂F: m-Me, 85, b_1.4 78.5-79°, n²⁵_D 1.4909; ο-MeO, 42, m. 39-40°; p-AcNH (I), 47, m. 176°; m-Cl, 63, b_0.8 69-70°, n²⁵_D 1.5114; m-Br, 63, b_1.0 90°, n²⁵_D 1.5358; p-O₂N (II), 65, m. 77.5-8.5°. I is best prepared in aqueous dioxane. Reduction of II with Sn and HCl gives p-H₂NC₆H₄SO₂F (45%), m. 72-3°, converted into I by Ac₂O in AcOH. In the experiment, the researchers used many compounds, for example, 3-Bromobenzene-1-sulfonyl fluoride (cas: 454-65-9Recommanded Product: 454-65-9).

3-Bromobenzene-1-sulfonyl fluoride (cas: 454-65-9) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Recommanded Product: 454-65-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

N-alkoxy-N-acylnitrenium ions in intramolecular aromatic addition reactions was written by Glover, Stephen A.;Goosen, Andre;McCleland, Cedric W.;Schoonraad, Johan L.. And the article was included in Tetrahedron in 1987.Electric Literature of C10H13BrO This article mentions the following:

N-Alkoxy-N-acylnitrenium ions are generated by treating N-alkoxy-N-chloroamides with Ag⁺ ions in ethereal solvents. These intermediates readily cyclize onto aromatic nuclei on alkoxy side chains to give benzoxazines and benzoxazepines and on acyl side chains to give γ-, δ-, and ε-benzolactams. E.g., treating Ph(CH₂)₃ONClBz in Et₂O with AgBF₄ gave 50% benzoxazepine I. Spirane products are formed by ipso addition when a 4-methoxy substituent is present on the side chain aromatic rings. The yields and regioselectivities of these reactions are ascribed to different transition structures for cyclization onto the acyl and alkoxy side chains, which involve an exo- and endocyclic N⁺-O π-bond, resp. Evidence for this exceptionally high π-bond character is obtained from MNDO calculations, which predict a π-bond order of 0.9 and a rotational barrier of 29.7 kcal mol^-1. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Electric Literature of C10H13BrO).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Electric Literature of C10H13BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Metal free synthesis of 1,3-diynes through C_sp-C_sp homo- and hetero-coupling reaction of terminal alkynes was written by Tamuli, Kashyap J.;Bordoloi, Manobjyoti. And the article was included in Sustainable Chemistry and Pharmacy in 2022.Recommanded Product: 128-08-5 This article mentions the following:

Recent methodologies aimed at utilization of eco-friendly pathways and sustainable chem. has turned out to be a convergent point in chem. research. With an objective to derive an economical, greener approach, herein, authors report a mild and straightforward synthetic strategy to synthesize a series of substituted sym. and unsym. 1,3-diyne derivatives This metal free synthetic route catalyzed by N-Bromosuccinimide with tBuOK and KF as fluorine source at room temperature affords excellent yields up to 95% within 2 h. Such type of a greener and sustainable process was adopted for the development of organic building blocks or compounds with minimal waste afford to define the most of the green chem. principles. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Recommanded Product: 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Recommanded Product: 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Arylation of aryllithiums with S-arylphenothiazinium ions for biaryl synthesis was written by Morofuji, Tatsuya;Yoshida, Tatsuki;Tsutsumi, Ryosuke;Yamanaka, Masahiro;Kano, Naokazu. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020.SDS of cas: 162258-89-1 This article mentions the following:

Herein, arylation of aryllithiums ArLi (Ar = Ph, 4-MeOC₆H₄, 1-naphthyl, etc.) with S-arylphenothiazinium ions I (R¹ = H, 4-Br, 4-t-Bu, etc.) through selective ligand coupling of intermediary sulfuranes is reported. Various unsym. biaryls II (R¹ = H, 4-Br, 4-SMe, etc.; R² = H, 4-Cl, 4-I, etc.) could be obtained without transition-metal catalysis. In the experiment, the researchers used many compounds, for example, 4-Bromo-4′-tert-butylbiphenyl (cas: 162258-89-1SDS of cas: 162258-89-1).

4-Bromo-4′-tert-butylbiphenyl (cas: 162258-89-1) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.SDS of cas: 162258-89-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and Characterization of Arsenolipids: Naturally Occurring Arsenic Compounds in Fish and Algae was written by Taleshi, Mojtaba S.;Seidler-Egdal, Rune K.;Jensen, Kenneth B.;Schwerdtle, Tanja;Francesconi, Kevin A.. And the article was included in Organometallics in 2014.Electric Literature of C15H29BrO2 This article mentions the following:

Arsenic-containing lipids (arsenolipids) are natural products present in fish and algae. Because these compounds occur in foods, there is considerable interest in their human toxicol. We report the synthesis and characterization of seven arsenic-containing lipids, including six natural products. The compounds comprise dimethylarsinyl groups attached to saturated long-chain hydrocarbons (three compounds), saturated long-chain fatty acids (two compounds), and monounsaturated long chain fatty acids (two compounds). The arsenic group was introduced through sodium dimethylarsenide or bis(dimethylarsenic) oxide. The latter route provided higher and more reproducible yields, and consequently, this pathway was followed to synthesize six of the seven compounds Mass spectral properties are described to assist in the identification of these compounds in natural samples. The pure synthesized arsenolipids will be used for in vitro experiments with human cells to test their uptake, biotransformation, and possible toxic effects. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2Electric Literature of C15H29BrO2).

15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Electric Literature of C15H29BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Intrinsic Turn-On Response of Thioflavin T in Complexes was written by Kung, Jocky C. K.;Vurgun, Nesrin;Chen, JoAnn C.;Nitz, Mark;Jockusch, Rebecca A.. And the article was included in Chemistry – A European Journal in 2020.SDS of cas: 53784-83-1 This article mentions the following:

The fluorescence enhancement (“turn-on”) response of the amyloid-sensing dye thioflavin T (ThT) is examined in vacuo, where solvent interactions are absent. “Upon the complexation of ThT with a derivatized β-cyclodextrin, heptakis-[6-deoxy-6-(3-sulfanylpropanoic acid)]-β-cyclodextrin, turn-on responses in both the gas phase and solution phase were observed In contrast, turn-on response was not detected when ThT was bound to gaseous cucurbit[7]uril or human telomeric DNA 22AG, whereas clear turn-on response occurs in solution The observed difference in turn-on response in the gas phase emphasizes the key interplay between chromophore, host and solvent and demonstrates the utility of gas-phase spectroscopy to tease out the balance among intermol. forces driving the behavior of important chromophores in solution In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1SDS of cas: 53784-83-1).

Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.SDS of cas: 53784-83-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and antiproliferative activity of marine bromotyrosine purpurealidin I and its derivatives was written by Bhat, Chinmay;Ilina, Polina;Tilli, Irene;Voracova, Manuela;Bruun, Tanja;Barba, Victoria;Hribernik, Nives;Lillsunde, Katja-Emilia;Maki-Lohiluoma, Eero;Ruffer, Tobias;Lang, Heinrich;Yli-Kauhaluoma, Jari;Kiuru, Paula;Tammela, Paivi. And the article was included in Marine Drugs in 2018.Formula: C8H6Br2O2 This article mentions the following:

The first total synthesis of the marine bromotyrosine purpurealidin I (1) using trifluoroacetoxy protection group and its dimethylated analog (29) is reported along with 16 simplified bromotyrosine derivatives lacking the tyramine moiety. Their cytotoxicity was evaluated against the human malignant melanoma cell line (A-375) and normal skin fibroblast cells (Hs27) together with 33 purpurealidin-inspired simplified amides, and the structure-activity relationships were investigated. The synthesized simplified analogs without the tyramine part retained the cytotoxic activity. Purpurealidin I (1) showed no selectivity but its simplified pyridin-2-yl derivative (36) had the best improvement in selectivity (Selectivity index 4.1). This shows that the marine bromotyrosines are promising scaffolds for developing cytotoxic agents and the full understanding of the elements of their SAR and improving the selectivity requires further optimization of simplified bromotyrosine derivatives In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Formula: C8H6Br2O2).

3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Formula: C8H6Br2O2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The Effect of Surface Polarity on the Electrochemical Double Layer and Its Influence on the Measurement of the Standard Rate Constant of Electron Transfer was written by Eggers, Paul K.;Hibbert, D. Brynn;Paddon-Row, Michael N.;Gooding, J. Justin. And the article was included in Journal of Physical Chemistry C in 2009.Product Details of 56523-59-2 This article mentions the following:

The influence of surface polarity and, hence, the elec. double layer on long-range electron transfer was studied using 35 different electrode constructs. These constructs were prepared using 5 different lengths of ferrocene-modified alkanethiols (of general formula HS(CH₂)_nCONHCH₂Fc where n was 7, 10, 11, 14, and 15 and Fc refers to ferrocene) mixed with an appropriate ratio of hydroxyl-terminated to Me-terminated alkanethiols as diluents. The mixtures of diluents in different ratios served not only to sep. and dilute the redox-active species but also to control the surface polarity of the self-assembled monolayer (SAM). The ratios of the 3 components in each SAM were 1:20:0, 1:16.6:3.4, 1:13.4:6.6, 1:10:10, 1:6.6:13.4, 1:16.6:3.4, and 1:0:20 of the ferrocene-, hydroxyl-, and Me-terminated species, resp. The formal redox potential and electron transfer rate constant were measured for each construct. It was found, 1st, that formal potentials changed according to the theory of interfacial potential distribution and, 2nd, that rate constants measured using cyclic voltammetry are strongly influenced by the Stern layer of the elec. double layer, which forms at the SAM-solution interface. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2Product Details of 56523-59-2).

15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Product Details of 56523-59-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Copper-Catalyzed Carboarylation of Alkynes via Vinyl Cations was written by Walkinshaw, Andrew J.;Xu, Wenshu;Suero, Marcos G.;Gaunt, Matthew J.. And the article was included in Journal of the American Chemical Society in 2013.Quality Control of 1-(2-Bromoethyl)-4-methoxybenzene This article mentions the following:

Copper-catalyzed arylation of electron rich alkynes reveals stabilized trisubstituted vinyl cation equivalent that react with pendant arene nucleophiles to form all carbon tetrasubstituted alkenes, e.g. I. The new process streamlines the synthesis of important medicinally relevant mols. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Quality Control of 1-(2-Bromoethyl)-4-methoxybenzene).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Quality Control of 1-(2-Bromoethyl)-4-methoxybenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bis(4â€?tert-butylbiphenyl-4-yl)aniline (BBA)-substituted A₃B zinc porphyrin as light harvesting material for conversion of light energy to electricity was written by Duvva, Naresh;Gangada, Suneel;Chitta, Raghu;Giribabu, Lingamallu. And the article was included in Journal of Porphyrins and Phthalocyanines in 2020.Name: 4-Bromo-4′-tert-butylbiphenyl This article mentions the following:

Limited synthetic steps via low-cost starting materials are needed to develop large-scale light-active materials for efficient solar cells. Here, novel bis(4â€?tert-butylbiphenyl-4-yl)aniline (BBA) based A3B zinc porphyrin (GB) is synthesized and applied as a light harvesting/electron injection material in dye-sensitized solar cells. The GB sensitizer was characterized by various spectroscopic techniques and the optimized device shows JSC of 10.98 ± 0.37 mA/cm² and power conversion efficiency (PCE) of 3.34 ± 0.26%. In addition, performance is enhanced up to _~3.9% by the addition of co-adsorbent 3a,7a-dihydroxy-5b-cholic acid (chenodeoxycholic acid, CDCA) to minimize π-π staking of the planar porphyrin macrocycles. These results demonstrate that novel broad-absorbing light-active material (GB) could be used for indoor solar panels. In the experiment, the researchers used many compounds, for example, 4-Bromo-4′-tert-butylbiphenyl (cas: 162258-89-1Name: 4-Bromo-4′-tert-butylbiphenyl).

4-Bromo-4′-tert-butylbiphenyl (cas: 162258-89-1) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Name: 4-Bromo-4′-tert-butylbiphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary