Synthesis of 4-fluoro-3-phenoxytoluene was written by Zhao, Wen-xian;Wang, De-kun;Zhou, Yan-li. And the article was included in Jingxi Huagong in 2004.Application of 452-62-0 This article mentions the following:
4-Fluoro-3-phenoxytoluene (I) was synthesized by Ullmann coupling reaction of 3-bromo-4-fluorotoluene (II) and phenol. When the molar ratio of PhONa to II was 3:1 with 15% (mol) of CuO as catalyst and DMA as solvent, the reaction ran at 160 閳?165 鎺矯 for 5 h to give I in 88% yield. The structure of I was confirmed by elementary anal., 1HNMR, IR, and MS. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0Application of 452-62-0).
3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Application of 452-62-0
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary