Zhao, Peng et al. published their research in European Journal of Medicinal Chemistry in 2022 | CAS: 945244-29-1

5-Bromo-2-fluoro-4-methylaniline (cas: 945244-29-1) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Formula: C7H7BrFN

Discovery of spiro amide SHR902275: A potent, selective, and efficacious RAF inhibitor targeting RAS mutant cancers was written by Zhao, Peng;Zhuang, Linghang;Wang, Xiangzhu;Huang, Song;Wu, Heping;Zhou, Yu;Yan, Yuna;Zhang, Fan;Shen, Ru;Li, Jing;Liu, Suxing;Zhang, Rumin;Dong, Ping;Mao, Yuchang;Fan, Yuanmin;He, Chunyong;Sun, Jiakang;Zhang, Lei;Hu, Qiyue;Wan, Hong;Feng, Jun;Bai, Chang;He, Feng;Tao, Weikang. And the article was included in European Journal of Medicinal Chemistry in 2022.Formula: C7H7BrFN This article mentions the following:

The RAS-RAF-MEK-ERK signaling pathway plays a key role to regulate multiple cellular functions. Acquired resistance to the first-generation RAF inhibitors that only targeted the bRAFV600E mutation prompted the need for a new generation of RAF inhibitors to target cancers bearing mutant RAS and wild type RAF activity by inhibition of paradoxical activation. Starting from the company’s previously reported RAF inhibitor 1 (I), extensive drug potency and drug-like properties optimizations led to the discovery of mol. 33 (SHR902275, II) with greatly improved in vitro potency and solubility Mol. 33 exhibited good DMPK (Drug Metabolism and Pharmacokinetics) properties, excellent permeability, and outstanding mouse/rat oral PK. It was further evaluated in an in vivo RAS mutant Calu6 xenograft mouse model and demonstrated dose dependent efficacy. To achieve high exposure in a toxicity study, pro-drug 48 (III) was also explored. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-fluoro-4-methylaniline (cas: 945244-29-1Formula: C7H7BrFN).

5-Bromo-2-fluoro-4-methylaniline (cas: 945244-29-1) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Formula: C7H7BrFN

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary