Oleanolic acid and its derivatives: New inhibitor of protein tyrosine phosphatase 1B with cellular activities was written by Zhang, Yi-Nan;Zhang, Wei;Hong, Di;Shi, Lei;Shen, Qiang;Li, Jing-Ya;Li, Jia;Hu, Li-Hong. And the article was included in Bioorganic & Medicinal Chemistry in 2008.HPLC of Formula: 6515-58-8 This article mentions the following:
Protein tyrosine phosphatase 1B is a key factor in the neg. regulation of insulin pathway and a promising target for treatment of diabetes and obesity. Herein, a series of competitive inhibitors were optimized from oleanolic acid, a natural triterpenoid identified against PTP1B by screening libraries of traditional Chinese medicinal herbs. Modifying at 3 and 28 positions, the authors obtained compound (I) with a Ki of 130 nM, which exhibited good selectivity between other phosphatases involved in insulin pathway except T-cell protein tyrosine phosphatase. Further evaluation in cell models illustrated that the derivatives enhanced insulin receptor phosphorylation in CHO/hIR cells and also stimulated glucose uptake in L6 myotubes with or addition of without insulin. In the experiment, the researchers used many compounds, for example, 3-(Bromomethyl)benzoic acid (cas: 6515-58-8HPLC of Formula: 6515-58-8).
3-(Bromomethyl)benzoic acid (cas: 6515-58-8) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.HPLC of Formula: 6515-58-8
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary