Development of Phthalimide-Donepezil Hybrids as Potent Multitarget- Directed Ligands for the Treatment of Alzheimer’s Disease was written by Yu, Lintao;Shi, Jian;Cheng, Xinfeng;Wang, Keren;Liu, Shuang;Liu, Wenmin;Sang, Zhipei. And the article was included in Letters in Drug Design & Discovery in 2020.COA of Formula: C13H14BrNO2 This article mentions the following:
Due to the complex etiol. of AD, multi-target-directed ligands (MTDLs), combining two or more distinct pharmacol. moieties, have been developed in both symptomatic and disease-modifying efficiencies and are considered as an effective way for the treatment of AD. To test their biol. activities, including AChE/BChE inhibitory activity and MAOA/ MAO-B inhibitory activity. In addition, mol. modeling studies were performed to afford insight into the binding mode. The results displayed that compound 4c showed the best AChE inhibitory activity with an IC50 value of 4.2 I1/4M, which was supported by the kinetic study and docking study. Compound 4c was also a selective MAO-B inhibitor (IC50 = 8.2 I1/4M). Moreover, compound 4c could cross the blood-brain barrier in vitro. Compound 4c deserved to further study as a potential multifunctional agent for the treatment of Alzheimeraeuros disease. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4COA of Formula: C13H14BrNO2).
N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon闂佺偨鍎茶ぐ绲﹐mine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.COA of Formula: C13H14BrNO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary