Synthesis and fungicidal activities of boscalid and its analogs was written by Yu, Kang-ping;Li, Ze-fang;Yin, Hong-bo;Liu, Mu-lan;Li, Hui. And the article was included in Xiandai Nongyao in 2015.Safety of 4-Bromo-4′-tert-butylbiphenyl This article mentions the following:
A novel method was employed for preparing boscalid and its alkyl analogs via Friedel-Crafts alkylation, nitration, reduction, condensation, and reverse Friedel-Crafts alkylation from 4-halobiphenyl. Then boscalid and seven analogs were confirmed by 1H NMR, mass spectrum and IR anal. Preliminary bioassays indicated that the target compounds were effective to some of tested pathogens at 50 mg/L. In the experiment, the researchers used many compounds, for example, 4-Bromo-4′-tert-butylbiphenyl (cas: 162258-89-1Safety of 4-Bromo-4′-tert-butylbiphenyl).
4-Bromo-4′-tert-butylbiphenyl (cas: 162258-89-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Safety of 4-Bromo-4′-tert-butylbiphenyl
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary