Metal-Free Aerobic Oxidative Selective C-C Bond Cleavage in Heteroaryl-Containing Primary and Secondary Alcohols was written by Xia, Anjie;Qi, Xueyu;Mao, Xin;Wu, Xiaoai;Yang, Xin;Zhang, Rong;Xiang, Zhiyu;Lian, Zhong;Chen, Yingchun;Yang, Shengyong. And the article was included in Organic Letters in 2019.Application of 18791-79-2 This article mentions the following:
A transition-metal-free aerobic oxidative selective C-C bond-cleavage reaction in primary and secondary heteroaryl alcs. is reported. This reaction was highly efficient and tolerated various heteroaryl alcs., generating a carboxylic acid derivative and a neutral heteroaromatic compound Exptl. studies combined with d. functional theory calculations revealed the mechanism underlying the selective C-C bond cleavage. This strategy also provides an alternative simple approach to carboxylation reaction. In the experiment, the researchers used many compounds, for example, 5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2Application of 18791-79-2).
5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Application of 18791-79-2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary