Synthesis of 浼?Aryl Esters and Nitriles: Deaminative Coupling of 浼?Amino-Esters and 浼?Aminoacetonitriles with Arylboronic Acids was written by Wu, Guojiao;Deng, Yifan;Wu, Chaoqiang;Zhang, Yan;Wang, Jianbo. And the article was included in Angewandte Chemie, International Edition in 2014.Related Products of 2178-24-7 This article mentions the following:
Transition-metal-free synthesis of 浼?aryl esters and nitriles using arylboronic acids with 浼?amino esters and 浼?(amino)acetonitrile derivatives, resp., as starting materials has been developed. The reaction represents a rare case of converting C(sp3)-N bonds (carbon-nitrogen bonds) into C(sp3)-C(sp2) bonds (carbon-carbon bonds). The reaction conditions are mild, demonstrate good functional-group tolerance, and can be scaled up. The synthesis of the target compounds was achieved using glycine ester hydrochloride, leucine ester hydrochloride, aspartate ester hydrochloride, alanine ester hydrochloride as starting materials in a reaction with (aryl)boronic acids. The title compounds thus formed included benzeneacetic acid esters, 1-naphthaleneacetic acid ester, benzenepropanoic acid esters, 浼?phenyl-1H-indole-3-propanoic acid ester, benzenebutanoic acid ester and similar substances. A reaction of (aryl)boronic acids with 浼?(amino)acetonitrile gave 浼?(alkyl)benzeneacetonitrile derivatives Nitriles included 浼?(hexyl)benzeneacetonitrile, 浼?phenyl-3-thiophenepropanenitrile and similar compounds In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Related Products of 2178-24-7).
Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Related Products of 2178-24-7
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary