Palladium(0) catalyzed cross coupling reactions of hindered, double activated aryl halides with organozinc reagents – the effect of copper(I) cocatalysis was written by Weichert, Andreas;Bauer, Martina;Wirsig, Petra. And the article was included in Synlett in 1996.Safety of Methyl 4-bromo-3-(trifluoromethyl)benzoate This article mentions the following:
Various organozinc reagents undergo palladium(0) catalyzed Negishi-Kumada-type cross coupling reactions, cocatalyzed by copper(I) iodide, with electronically activated aryl halides in the presence of an electron withdrawing ortho or meta substituent and an ester group. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-3-(trifluoromethyl)benzoate (cas: 107317-58-8Safety of Methyl 4-bromo-3-(trifluoromethyl)benzoate).
Methyl 4-bromo-3-(trifluoromethyl)benzoate (cas: 107317-58-8) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Safety of Methyl 4-bromo-3-(trifluoromethyl)benzoate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary