A highly practical and convenient halogenation of fused heterocyclic N-oxides was written by Wang, Dong;Wang, Yuxi;Zhao, Junjie;Li, Linna;Miao, Longfei;Wang, Dong;Sun, Hua;Yu, Peng. And the article was included in Tetrahedron in 2016.Synthetic Route of C12H7BrN2 This article mentions the following:
A novel, simple and practical method for the regioselective halogenation of fused heterocyclic N-oxides was developed. It employs Vilsmeier reagent, generated in situ by POX3 and DMF, as both the activating agent and the nucleophilic halide source. The method is amenable across a broad range of substrates, including quinolines, isoquinolines and the diazine N-oxides, possessing a variety of substitution patterns. Furthermore, all of the reagents associated are cheap and easy to obtain. The potential extension of this method to a one-pot oxidation/halogenation sequence that obviates the need for isolation of the N-oxide intermediates is also presented. In the experiment, the researchers used many compounds, for example, 2-Bromo-1,10-phenanthroline (cas: 22426-14-8Synthetic Route of C12H7BrN2).
2-Bromo-1,10-phenanthroline (cas: 22426-14-8) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Synthetic Route of C12H7BrN2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary