An efficient Pd(II)-(2-aminonicotinaldehyde) complex as complementary catalyst for the Suzuki-Miyaura coupling in water was written by Thunga, Sanjeeva;Poshala, Soumya;Anugu, Naveenkumar;Konakanchi, Ramaiah;Vanaparthi, Satheesh;Kokatla, Hari Prasad. And the article was included in Tetrahedron Letters in 2019.Computed Properties of C16H17Br This article mentions the following:
An efficient new Pd(II)-(2-aminonicotinaldehyde)-catalyzed Suzuki-Miyaura coupling of the aryl halides RX (R = Ph, thiophen-2-yl, 4-(imidazo[1,2-a]pyridin-2-yl)phenyl, etc.; X = Br, Cl, I) and organoboronic acids ArB(OH)2 (Ar = Ph, 3,5-dimethylphenyl, naphthalen-1-yl, etc.) at moderate temperature in water is described. Low catalyst loading, easy accessibility, being an air-stable catalyst, functional group compatibility, and water as the reaction medium are some of the key features of this synthetic method. This protocol is also applicable for gram scale. In the experiment, the researchers used many compounds, for example, 4-Bromo-4′-tert-butylbiphenyl (cas: 162258-89-1Computed Properties of C16H17Br).
4-Bromo-4′-tert-butylbiphenyl (cas: 162258-89-1) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Computed Properties of C16H17Br
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary