Metal free synthesis of Coumarin containing hetero[n]helicene like molecules with TICT and AIE properties was written by Soni, Rina;Soman, Shubhangi S.. And the article was included in Asian Journal of Organic Chemistry in 2022.Safety of 1-Bromopyrrolidine-2,5-dione This article mentions the following:
Coumarin containing hetero[n]helicene like mols. were synthesized using three component Povarov reaction followed by two dehydrogenation steps in good yields. Synthesis and photophys. properties of coumarin containing multifunctional helicene like mols. were found to be affected by substitution on pendant Ph ring. Coumarin containing hetero[6]helicene like derivative 4-(4-nitrophenyl)-2H-benzo[f]benzo[5,6]chromeno[3,4-c]isoquinolin-2-one showed bright yellow emission in solution, thin film and solid state. Coumarin containing hetero[6]helicene like compound 4-(2-oxo-5,6-dihydro-2H-chromeno[3,4-c]naphtho[1,2-f]isoquinolin-4-yl)benzonitrile showed bright blue emission in solution, thin film, and solid state. The structures of intermediate compounds were confirmed by a single crystal X-ray anal. These structures were compared with DFT optimized structures for the helicity parameters. DFT calculations provided good correlation with observed photophys. properties of compounds 4-(4-Nitrophenyl)-2H-benzo[f]benzo[5,6]chromeno[3,4-c]isoquinolin-2-one and 4-(2-oxo-5,6-dihydro-2H-chromeno[3,4-c]naphtho[1,2-f]isoquinolin-4-yl)benzonitrile. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Safety of 1-Bromopyrrolidine-2,5-dione).
1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Safety of 1-Bromopyrrolidine-2,5-dione
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary