Electroorganic chemistry. 91. A novel base useful for synthesis of esters and macrolides was written by Shono, Tatsuya;Ishige, Osamu;Uyama, Hiroshi;Kashimura, Shigenori. And the article was included in Journal of Organic Chemistry in 1986.Category: bromides-buliding-blocks This article mentions the following:
The anionic species (I) formed by the electroreduction of 2-pyrrolidone in DMF in the presence of tetraalkylammonium salts was a highly efficient base for the esterification of acids such as gibberellic and 6-aminopenicillanic acids which are not always stable under the usual esterification conditions. I was also useful for the selective transformation of 锠?halo carboxylic acids to the corresponding macrolides. The effect of the bulkiness of the supporting electrolytes on the selectivity of formation of macrolides over diolides was also discussed. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2Category: bromides-buliding-blocks).
15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Category: bromides-buliding-blocks
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary