Regulation of Protein Binding Capability of Surfaces via Host-Guest Interactions: Effects of Localized and Average Ligand Density was written by Shi, Xiujuan;Zhan, Wenjun;Chen, Gaojian;Yu, Qian;Liu, Qi;Du, Hui;Cao, Limin;Liu, Xiaoli;Yuan, Lin;Chen, Hong. And the article was included in Langmuir in 2015.Safety of Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin This article mentions the following:
The protein binding capability of biomaterial surfaces can significantly affect subsequent biol. responses, and appropriate ligand presentation is often required to guarantee the best functions. Herein, a new facile method for regulating this capability by varying the localized and average ligand d. is presented. Binding between lysine and plasminogen relevant to a fibrinolysis system was chosen as a model. We integrated different lysine-modified 灏?cyclodextrin (灏?CD) derivatives onto bioinert copolymer brushes via host-guest interactions. The localized and average lysine d. can be conveniently modulated by changing the lysine valency on 灏?CD scaffolds and by diluting lysine-persubstituted 灏?CD with pure 灏?CD, resp. Both the plasminogen adsorption and the plasminogen binding affinity were enhanced by lysine-persubstituted 灏?CD compared with those of lysine-monosubstituted 灏?CD, which is possibly due to the higher localized lysine d. and the multivalent binding of plasminogen on lysine-persubstituted 灏?CD surfaces. With a change in the ratio of lysine-persubstituted 灏?CD to 灏?CD, the average lysine d. can be tuned, leading to the linear regulation of the adsorption of plasminogen on surfaces. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1Safety of Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin).
Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Safety of Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary