Magnetic glyconanoparticles for selective lectin separation and purification was written by Oz, Yavuz;Abdouni, Yamin;Yilmaz, Gokhan;Becer, C. Remzi;Sanyal, Amitav. And the article was included in Polymer Chemistry in 2019.Name: Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin This article mentions the following:
A modular platform for the separation and purification of lectins using polymer coated iron oxide nanoparticles is developed. Supramol. host-guest interactions based on an adamantane beta-cyclodextrin (灏?CD) dyad are utilized to modify the polymeric interface. Poly(ethylene glycol) based hydrophilic polymer-coated magnetic iron oxide nanoparticles are fabricated using reversible addition-fragmentation chain transfer polymerization, followed by their chain-end modification to install adamantane groups on the nanoparticle surface. These adamantyl containing nanoparticles could be surface modified using 灏?CDs appended with appropriate ligands for intended applications. In this study, we exploit this supramol. system for the purpose of separation and purification of lectins. Therefore, a polymer-coated magnetic nanoparticle interface was decorated with two types of mannose-containing 灏?CD constructs, a monodisperse heptamannose conjugated CD and a CD-based 7-arm star shaped glycopolymer for selective binding towards the Con A (ConA) lectin. The monodisperse and polydisperse CD derivatives were compared in terms of their efficiency for binding to ConA. It was demonstrated that the polymeric CD construct significantly improved the binding of magnetic nanoparticles and provided an effective system for the separation and purification of ConA from a mixture of ConA and peanut agglutinin (PNA). Moreover, the surface bound isolated protein could be simply regenerated by the addition of competitive ligands such as mannose. Specificity to bind a particular lectin can be tailored by choosing the appropriate sugar based ligand, as demonstrated by the specific capture of PNA using a galactose-containing polymer. The modular nature of functionalization of the nanoparticle interface that is tunable by host-guest chem. affords a universal system that can be easily tailored for the purification of specific proteins from mixtures In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1Name: Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin).
Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Name: Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary