Domino Direct Arylation and Cross-Aldol for Rapid Construction of Extended Polycyclic 锜?Scaffolds was written by Nitti, Andrea;Bianchi, Gabriele;Po, Riccardo;Swager, Timothy M.;Pasini, Dario. And the article was included in Journal of the American Chemical Society in 2017.Synthetic Route of C10H11BrO2 This article mentions the following:
Five-membered aromatic heterocycles are a ubiquitous skeleton of 锜?conjugated organic compounds, and their incorporation requires synthetic protocols that are not easily industrially sustainable or scalable. Improved methodologies for their insertion into 锜?scaffolds are therefore necessary. We report an efficient and scalable protocol involving a one-pot cross-Aldol direct arylation reaction protocol for the rapid construction of thiophene- and furan-based 锜?extended organic materials. In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Synthetic Route of C10H11BrO2).
Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Synthetic Route of C10H11BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary