Intramolecular Direct Arylation of 1,3-Diketone-Derived Enol Ethers in a Synthesis of Tricyclic Oxoisochromene Derivatives was written by Muimhneachain, Eoin O.;Pardo, Leticia M.;Bateman, Lorraine M.;Rao Khandavilli, U. B.;Lawrence, Simon E.;McGlacken, Gerard P.. And the article was included in Advanced Synthesis & Catalysis in 2017.HPLC of Formula: 61150-57-0 This article mentions the following:
A synthesis of tricyclic oxoisochromene derivatives via an intramol. direct arylation of cycloalkyl-1,3-diketone-derived 浼?灏?unsaturated ketone substrates is described. Interesting mechanistic insight has been gathered, based on deuterium migration studies, induced by palladium (Pd). In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0HPLC of Formula: 61150-57-0).
2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.HPLC of Formula: 61150-57-0
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary