Zirconium-Catalyzed Remote Defunctionalization of Alkenes was written by Matt, Christof;Kern, Christoph;Streuff, Jan. And the article was included in ACS Catalysis in 2020.Synthetic Route of C5H11BrO This article mentions the following:
This work introduces a catalytic zirconium chain-walk reaction that in combination with a 閻?heteroatom elimination step enables the cleavage of remote nonactivated carbon-heteroatom bonds. The result is a controlled defunctionalization reaction, which takes place with excellent site selectivity and can be applied to sym. and unsym. alkene chains with ether, amine, and thioether groups. The approach can be used for remote functional group substitution as well, and a preliminary investigation indicates a dissociative chain-walk mechanism. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Synthetic Route of C5H11BrO).
1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Synthetic Route of C5H11BrO
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary