Synthesis of compounds allied to rhododendrin was written by Kim, Ki-U. And the article was included in Yakugaku Zasshi in 1943.HPLC of Formula: 57293-19-3 This article mentions the following:
In order to exam. the pharmacol. action of compounds allied to rhododendrin, the following compounds were synthesized. 1-(p-Hydroxyphenyl)-2-propanol: p-MeOC6H4CH:CHMe(+ Br) 闂?MeOC6H4CHBrCHBrMe (+ CaO) 闂?MeOC6H4CH(OH)CHBrMe (+ 2.5% alkali) 闂?MeOC6H4CH(OH)CH(OH)Me (heating to 180闁? 闂?MeOC6H4CH2COMe (+ Na + EtOH) 闂?MeOC6H4CH2CH(OH)Me (+ Grignard reagent) 闂?p-HOC6H4CH2CH(OH)Me. 5-(p-Hydroxyphenyl)-2-pentanol: p-MeOC6H4CHO + AcOEt (+ Na) 闂?MeOC6H4CH:CHCO2Et (+ H) 闂?MeOC6H4CH2CH2CO2Et (+ Na + AmOH) 闂?MeOC6H4(CH2)3OH (+ PBr3) 闂?MeOC6H4(CH2)3Br 闂?MeOC6H4(CH2)3CN (+ MeMgI) 闂?MeOC6H4(CH2)3COMe 闂?MeOC6H4(CH2)3CH(OH)Me 闂?HOC6H4(CH2)3CH(OH)Me. By similar methods were prepared: 6-(p-hydroxyphenyl)-2-hexanol, from p-MeOC6H4CHO and EtCOMe; 1-(m-hydroxyphenyl)-3-butanol, from m-MeOC6H4CHO and Me2CO; 1-(4-hydroxy-3-methoxyphenyl)-3-butanol, from vanillin and Me2CO; 1-(p-hydroxyphenyl)-3-pentanol, from p-MeOC6H4CHO and AcOEt; 1-(4-hydroxy-3-methylphenyl)-3-butanol from 3,4-Me(HO)C6H3CHO (prepared from m-MeC6H4OH, HCN, AlCl3, and HCl) and Me2CO; 1-(4-hydroxy-2-methylphenyl)-3-butanol, from 2,4-Me(HO)C6H3CHO and Me2CO; and 1-(4-hydroxy-5-isopropyl-2-methylphenyl)-3-butanol, from 5,2-Me(Me2CH)C6H3OH through 2,5,4-Me(Me2CH)(HO)C6H2CHO. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3HPLC of Formula: 57293-19-3).
1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. HPLC of Formula: 57293-19-3
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary