Syntheses and first crystal structures of rhenium complexes derived from 锠?functionalized fatty acids as model compounds of technetium tracers for myocardial metabolism imaging was written by Jung, Christian M.;Kraus, Werner;Leibnitz, Peter;Pietzsch, Hans-Jurgen;Kropp, Joachim;Spies, Hartmut. And the article was included in European Journal of Inorganic Chemistry in 2002.Quality Control of 15-Bromopentadecanoic acid This article mentions the following:
In an attempt to develop new technetium-based radiopharmaceuticals for the noninvasive diagnosis of myocardial metabolism, the authors synthesized three examples of novel metal-containing fatty acid derivatives according to the “3+1” mixed-ligand and the Schiff base/tricarbonyl design, Re:O[S(CH2)2S(CH2)2S][S(CH2)11S(CH2)4CO2H] (7), Re:O[S(CH2)2NMe(CH2)2S][S(CH2)14CO2H] (10) and ReBr(CO)3[2-py-CH:N(CH2)11CO2H] (14). The chelates contain the metal core in the oxidation states +5 (7 and 10) and +1 (14) and are attached to the end-position of a fatty acid chain. The complex formation was accomplished by ligand-exchange reactions with three different rhenium precursors, whereas the inactive rhenium metal was used as a surrogate of the technetium radionuclide. The mol. structures of the fatty acid complexes 7, 10 and 14 were determined by single-crystal x-ray diffraction analyses and impressively show a general problem in technetium tracer research, the significant structural alterations of bioactive mols. by coordination even to small metal chelates. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2Quality Control of 15-Bromopentadecanoic acid).
15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Quality Control of 15-Bromopentadecanoic acid
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary