Ni-Catalyzed reductive arylalkylation of unactivated alkenes was written by Jin, Youxiang;Wang, Chuan. And the article was included in Chemical Science in 2019.SDS of cas: 4457-67-4 This article mentions the following:
In this protocol Ni-catalyzed reductive arylalkylation of unactivated alkenes tethered to aryl bromides with primary alkyl bromides was accomplished, which provided a new path to construct diverse benzene-fused carbo- and heterocyclic cores including indanes, tetrahydroisoquinolines, indolines and isochromanes I [R1 = Me, Et, i-Pr, cyclohexyl; R2 = H, Me, Et; R3 = 5-OMe, 5-F, 4-Cl, etc.; R4 = CN, OAc, F, etc.; X = CH2, NH, NMe, O; m = 0,3,4,5,6; n = 0,1]. Notably, this new method circumvented the pregeneration of organometallics and demonstrated high tolerance to a wide range of functional groups. The preliminary mechanistic investigations suggested a reaction pathway with an intermediate reduction In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4SDS of cas: 4457-67-4).
1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.SDS of cas: 4457-67-4
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary