Cationic 灏?cyclodextrin derivative for chiral separations was written by Haynes, Judson L. III;Shamsi, Shahab A.;O’Keefe, Frank;Darcey, Raphel;Warner, Isiah M.. And the article was included in Journal of Chromatography A in 1998.Product Details of 53784-83-1 This article mentions the following:
A novel hepta-substituted 灏?cyclodextrin bearing the methoxyethylamine group linked to the upper cyclodextrin rim was successfully used as a chiral selector for enantiomeric separation of nonsteroidal anti-inflammatory drugs (NSAIDs) and phenoxypropionic acid herbicides (PPAHs). Separation parameters such as pH and concentration have major influences on enantiomeric resolution of the NSAIDs and PPAHs. Heptakis(6-methoxyethylamine-6-deoxy)-灏?cyclodextrin [灏?CD-OMe (VII)] performs exceptionally well for the enantiomeric resolution of NSAIDs: indoprofen and fenoprofen (Rs = 11 and 14, resp.). Baseline enantiomeric separation of a mixture of six pairs of PPAHs was achieved in under 30 min. Compared to other cationic 灏?cyclodextrins reported in the literature, the 灏?CD-OMe (VII) showed improved selectivity for both classes of the aforementioned anionic racemates. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1Product Details of 53784-83-1).
Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Product Details of 53784-83-1
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary