Fluorescent indolium dyes for applications in aqueous halide sensing-part 2: the repeated alkylation of Harmane post quaternisation was written by Geddes, C. D.. And the article was included in Dyes and Pigments in 2001.Application In Synthesis of 15-Bromopentadecanoic acid This article mentions the following:
The repeated alkylation of harmane (1-methyl-9H-pyrido[3,4-b]indole) after quaternization has been observed during fusion with 8-bromooctanoic acid (I). This can be explained by two possible competing mechanisms, the electrophilic addition of carboxyalkylating agent to the resonance enamine form of the initial quaternized product and/or oligoester formation between the quaternized product and I. The mechanisms are supported by 1H NMR, FTIR, and mass spectrometry anal., and by carboxyoctylation of 6-methoxyquinoline. The possibility for controlling the repeated alkylation in nanometer size silica pores, in essence restricted geometry nanometer size reaction vessels, is discussed. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2Application In Synthesis of 15-Bromopentadecanoic acid).
15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Application In Synthesis of 15-Bromopentadecanoic acid
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary