Synthesis of Quinazolines and Tetrahydroquinazolines: Copper-Catalyzed Tandem Reactions of 2-Bromobenzyl Bromides with Aldehydes and Aqueous Ammonia or Amines was written by Fan, Xuesen;Li, Bin;Guo, Shenghai;Wang, Yuanyuan;Zhang, Xinying. And the article was included in Chemistry – An Asian Journal in 2014.Recommanded Product: 2-Bromo-4-fluorobenzylbromide This article mentions the following:
An efficient synthesis of diversely substituted quinazolines and 1,2,3,4-tetrahydroquinazolines through copper-catalyzed tandem reactions of the readily available 2-bromobenzyl bromides, aldehydes, and aqueous ammonia or amines has been developed. By using ammonia and simple aliphatic amines as the nitrogen source, the present method provides a versatile and practical protocol for the synthesis of quinazolines and 1,2,3,4-tetrahydroquinazolines. E.g., in presence of Cu(OAc)2 and DMAP in DMSO at 80 鎺矯, reaction of 2-BrC6H4CH2Br, 4-MeC6H4CHO and aqueous ammonia gave 64% quinazoline derivative I. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Recommanded Product: 2-Bromo-4-fluorobenzylbromide).
2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Recommanded Product: 2-Bromo-4-fluorobenzylbromide
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary