Research in the azole series. XXVI. Nuclear magnetic resonance study and the reaction of 1,2,3-triazole with halo nitrobenzenes was written by Elguero, Jose;Gonzalez, Emmanuel;Jacquier, Robert. And the article was included in Bulletin de la Societe Chimique de France in 1967.Formula: C3H4BrN3 This article mentions the following:
Nucleophilic aromatic substitution of 1,2,3-triazole (I) is studied. An equimolar mixture of I and p-fluoronitrobenzene is heated 2 hrs. at 210鎺?in the presence of anhydrous KF to give a mixture of II, m. 206鎺? and III, m. 185鎺? With 1-fluoro-2,4-dinitrobenzene refluxed 6 hrs. with an equimolar amount of I, the only product isolated is IV, m. 127鎺? The same reaction with 1-chloro-2,4,6-trinitrobenzene leads only to V, m. 230鎺? The products are studied by N.M.R. in CDCl3, C6H6, Me2SO, (NMe2)3PO, C5D5N, CF3CO2H, and H2NNH2 solution, together with 1-methyl-1,2,3-triazole and 1-methyl-1,2,5-triazole. The chem. shifts are compared with calculated electron densities. 13C-1H coupling constants are determined for I and for its 1-Me derivative In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5Formula: C3H4BrN3).
4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Formula: C3H4BrN3
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary