An iron(II)-based metalloradical system for intramolecular amination of C(sp2)-H and C(sp3)-H bonds: synthetic applications and mechanistic studies was written by Das, Sandip Kumar;Das, Subrata;Ghosh, Supratim;Roy, Satyajit;Pareek, Monika;Roy, Brindaban;Sunoj, Raghavan B.;Chattopadhyay, Buddhadeb. And the article was included in Chemical Science in 2022.Recommanded Product: Ethyl (2-bromophenyl)acetate This article mentions the following:
A catalytic system for intramol. C(sp2)-H and C(sp3)-H amination of substituted tetrazolopyridines was successfully developed. The amination reactions were developed using an iron-porphyrin based catalytic system. It was demonstrated that the same iron-porphyrin based catalytic system efficiently activates both the C(sp2)-H and C(sp3)-H bonds of the tetrazole as well as azide-featuring substrates with a high level of regioselectivity. The method exhibited an excellent functional group tolerance. The method afforded three different classes of high-value N-heterocyclic scaffolds. A number of important late-stage C-H aminations were performed to access important classes of mols. Detailed studies (exptl. and computational) showed that both the C(sp2)-H and C(sp3)-H amination reactions involve a metalloradical activation mechanism, which is different from the previously reported electro-cyclization mechanism. Collectively, this study reports the discovery of a new class of metalloradical activation modes using a base metal catalyst that should find wide application in the context of medicinal chem., drug discovery and industrial applications. In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Recommanded Product: Ethyl (2-bromophenyl)acetate).
Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Recommanded Product: Ethyl (2-bromophenyl)acetate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary