The hemolytic properties of chemically modified cyclodextrins was written by Bost, Mireille;Laine, Valerie;Pilard, Florence;Gadelle, Andree;Defaye, Jacques;Perly, Bruno. And the article was included in Journal of Inclusion Phenomena and Molecular Recognition in Chemistry in 1997.Safety of Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin This article mentions the following:
The hemolytic properties of natural cyclodextrins, especially of the more common cyclomaltoheptaose entity, severely hamper their potential use as carriers in pharmaceutical applications where parenteral administration is concerned. A systematic investigation on the role of chem. modifications with regard to the hemolytic character was carried out involving C-6 branched neutral, anionic, cationic and amphoteric derivatives From these data, conclusions have been drawn about the charge and the geometry of the modification: (1) substitution at primary hydroxyl groups usually decreases the hemolytic character and the geometry of the substituent affects the hemolytic property; (2) introduction of an amino group, resulting in a pos. charge at physiol. pH, decreases the hemolytic character; (3) neg. charges are comparatively less effective in reducing the hemolytic character; (4) zwitterionic groups seem to enhance the hemolytic character of the cyclodextrin mol. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin (cas: 53784-83-1Safety of Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin).
Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Safety of Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary