The Skraup reaction of 3,4-dihaloanilines was written by Blatchly, Richard A.;Greeley, Michael A.;Markgraf, J. Hodge. And the article was included in Heterocycles in 1989.SDS of cas: 615-55-4 This article mentions the following:
Six 3,4-dihaloanilines I (R = Br, Cl, F; R1 = Br, Cl, F, iodo) were converted by the sulfo-mix variation of the Skraup reaction to mixtures of 5,6- and 6,7-dihaloquinolines, II and III resp. Inductive effects were the dominant influence on the course of cyclization: the more highly electron-withdrawing the substituents of I, the greater was the proportion of III. Steric effects were absent. In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4SDS of cas: 615-55-4).
3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.SDS of cas: 615-55-4
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary