Palladium-Catalyzed Regioselective Synthesis of 1-Hydroxycarbazoles Under Aerobic Conditions was written by Youn, So Won;Kim, Young Ho;Jo, Yoon Hyung. And the article was included in Advanced Synthesis & Catalysis in 2019.Recommanded Product: 192810-12-1 This article mentions the following:
A palladium-catalyzed aerobic C-H amidation of N-Ts-2-amino-3′-hydroxylbiaryls was developed to afford a diverse range of 1-hydroxycarbazoles with high regioselectivity and efficiency. This protocol benefits from operational simplicity, robustness, and sustainability using ambient air as the sole terminal oxidant. Further elaboration of the products obtained from this process provides facile access to various carbazole alkaloids including carbazolequinones and biscarbazoles. A mechanism involving dual directing group-assisted regioselective C-H activation at the more sterically hindered C2′-position of 2-amino-3′-hydroxylbiaryls is proposed. In the experiment, the researchers used many compounds, for example, Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1Recommanded Product: 192810-12-1).
Methyl 3-bromo-5-hydroxybenzoate (cas: 192810-12-1) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Recommanded Product: 192810-12-1
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary