Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators was written by Xing, Xuechao;Chang, Ling-Chu;Kong, Qiongman;Colton, Craig K.;Lai, Liching;Glicksman, Marcie A.;Lin, Chien-Liang Glenn;Cuny, Gregory D.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.SDS of cas: 83902-02-7 This article mentions the following:
Excitatory amino acid transporter 2 (EAAT2) is the major glutamate transporter and functions to remove glutamate from synapses. A thiopyridazine derivative I (R = 2-Cl-6-FC6H3CH2) has been found to increase EAAT2 protein levels in astrocytes. A structure-activity relationship study revealed that several components of the mol. were required for activity, such as the thioether and pyridazine. Modification of the benzyl thioether resulted in compounds I (R = 2,4-Me2C6H4CH2, 2,6-Me2C6H3CH2, 2-Cl-6-FC6H3CH2CH2) that enhanced EAAT2 levels by >6-fold at concentrations <5 μM after 24 h. In addition, the compound I (R = 2,6-Cl2C6H3CH2) enhanced EAAT2 levels 3.5-3.9-fold after 24 h with an EC50 of 0.5 μM. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7SDS of cas: 83902-02-7).
2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.SDS of cas: 83902-02-7
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary