Intramolecular palladium(
Palladium catalyzed β-C(sp3)-H activation of tertiary aldehydes RCH2C(R1)(R2)CHO [R = 2-Br-5-ClC6H3, 2-IC6H4, 2-Br-4-H3COC6H3, etc.; R1 = Me, Et, n-Pr; R2 = Me, Et] using a transient imine directing group enables intramol. arylation to form substituted indane-aldehydes I (R4 = H, 5-F, 4-Cl, 5-CF3, etc.). A simple amine bearing a Me ether (2-methoxyethan-1-amine) is the optimal TDG to promote C-H activation and reaction with an unactivated proximal C-Br bond. Substituent effects are studied in the preparation of various derivatives Preliminary mechanistic studies identify a reversible C-H activation and product inhibition and suggest that oxidative addition is the turnover limiting step. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Related Products of 61150-57-0).
2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Related Products of 61150-57-0
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary