Synthesis of novel potential DNA cross-linking new antineoplastic alkylating agents was written by Maroju, Sreedhar;Kumar, P. Naveen;Maroju, Ravichander;Velupula, Ganapathy;Haq, Abdul;Prasad, T. Ravi. And the article was included in Journal of Applicable Chemistry (Lumami, India) in 2014.Application In Synthesis of 3,4-Dibromoaniline This article mentions the following:
Twenty novel potential DNA crosslinking new antineoplastic alkylating agents, oxazolidin-2-ones I [R1 = H, Me, Br, F; R2 = OMe, morpholino, pyrrolidino, 3-pyridyl, etc.; R3 = N(CH2CH2Cl)2] were synthesized by the reaction I (R3 = NH2) with 1,2-dichloroethane in the presence of triethylamine in methylene dichloride under reflux. In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4Application In Synthesis of 3,4-Dibromoaniline).
3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Application In Synthesis of 3,4-Dibromoaniline
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary