Design, Synthesis, and Pharmacological Evaluation of Fused β-Homophenylalanine Derivatives as Potent DPP-4 Inhibitors was written by Jiang, Tao;Zhou, Yuren;Chen, Zhuxi;Sun, Peng;Zhu, Jianming;Zhang, Qiang;Wang, Zhen;Shao, Qiang;Jiang, Xiangrui;Li, Bo;Chen, Kaixian;Jiang, Hualiang;Wang, Heyao;Zhu, Weiliang;Shen, Jingshan. And the article was included in ACS Medicinal Chemistry Letters in 2015.Recommanded Product: 1-(Bromomethyl)-4-fluoro-2-nitrobenzene This article mentions the following:
Dipeptidyl peptidase-4 (DPP-4) inhibitors are accepted as a favorable class of agents for the treatment of type 2 diabetes. Herein, a series of fused β-homophenylalanine derivatives as novel DPP-4 inhibitors was designed, synthesized, and evaluated for their inhibitory activities against DPP-4. Most of them displayed excellent DPP-4 inhibitory activities and good selectivity. Among them, 9aa, 18a, and 18m also showed good efficacy in an oral glucose tolerance test (OGTT) in ICR mice. Moreover, when dosed 8 h prior to glucose challenge, 18m showed significantly greater potency than sitagliptin. It thus provides potential candidates for the further development into potent drugs targeting DPP-4. In the experiment, the researchers used many compounds, for example, 1-(Bromomethyl)-4-fluoro-2-nitrobenzene (cas: 76437-44-0Recommanded Product: 1-(Bromomethyl)-4-fluoro-2-nitrobenzene).
1-(Bromomethyl)-4-fluoro-2-nitrobenzene (cas: 76437-44-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Recommanded Product: 1-(Bromomethyl)-4-fluoro-2-nitrobenzene
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary