Nickel-catalyzed cross-electrophile coupling of aryl bromides and cyclic secondary alkyl bromides with spiro-bidentate-pyox ligands was written by Gao, Nanxing;Li, Yanshun;Cao, Guorui;Teng, Dawei. And the article was included in New Journal of Chemistry in 2021.Category: bromides-buliding-blocks This article mentions the following:
The cross-electrophile coupling of aryl bromides RBr [R = Ph, 4-(ethoxycarbonyl)phenyl, 1-(1H-indol-1-yl)ethan-1-one, etc.] and cyclic secondary alkyl bromides I [R1 = ethoxycarbonyl, (benzyloxy)carbonyl, (4-methylbenzene)sulfonyl, etc., X = (CH2)n, n = 1, 2] catalyzed by nickel/spiro-bidentate-pyox ligands, e.g., II, with lithium chloride as the additive for the Csp2-Csp3 bond formation is reported. The reaction could tolerate functional groups such as sulfonamide, ester, aldehyde, ketone, protected indolyl, tert-butoxycarbonyl, aryl nitriles and aryl chloride. Various aryl-cyclic secondary alkyl Csp2-Csp3 bond products, e.g., III, were synthesized under optimal reaction conditions (19 examples). In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Category: bromides-buliding-blocks).
Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Category: bromides-buliding-blocks
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary