Phosphabarrelenes as ligands in rhodium-catalyzed hydroformylation of internal alkenes essentially free of alkene isomerization was written by Fuchs, Evelyn;Keller, Manfred;Breit, Bernhard. And the article was included in Chemistry – A European Journal in 2006.Category: bromides-buliding-blocks This article mentions the following:
Despite significant research efforts in the past, one of the remaining problems to be solved in industrially important hydroformylation is the chemoselective low-pressure hydroformylation of internal alkenes. The authors prepare a new class of phosphabarrelenes (I, R = Ph (26%, 4a), i-Pr (35%, 4b), 2,4-xylyl (47%, 4c)) by Diels Alder reactions of benzyne with phosphabenzenes. Studies of the coordination properties of I, as well as results obtained in the Rh-catalyzed hydroformylation of cyclic and acyclic internal alkenes are reported. The rhodium/phosphabarrelene catalyst displays a very high activity towards hydroformylation with an unusually low tendency towards alkene isomerization. E.g., phosphabarrelene rhodium-catalyzed hydroformylation (4c/[Rh(CO)2acac], acac = acetylacetonate) of N-Boc-pyrroline gives exclusively the pyrroline 3-carboxaldehyde. The mol. structures of 4a and two phosphabarrelene rhodium complexes are determined by x-ray crystallog. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0Category: bromides-buliding-blocks).
3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Category: bromides-buliding-blocks
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary