The kinetics of the reactions of picryl chloride with some substituted anilines. Part 6. 4-Substituted and 3,4-disubstituted anilines was written by Emokpae, Thomas A.;Eguavoen, Osa;Khalil-Ur-Rahman;Hirst, Jack. And the article was included in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1980.Safety of 3,4-Dibromoaniline This article mentions the following:
Arrhenius parameters were determined for the reactions of picryl chloride in MeCN with substituted anilines: 4-RC6H4NH2 (R = F, Cl, Br, iodo, Me, OMe), 3,4-R2C6H3NH2 (R = Cl, Br, Me, OMe), 4,3-R(O2N)C6H3NH2 (R = F, Cl, Me), 3,4-R(MeO)C6H3NH2 (R = F, Cl, Br, iodo), 3,4-F(O2N)C6H3NH2 and 3,4,5-(MeO)3C6H2NH2. In the 3,4-disubstituted series the effect of 2 Me groups on the free energy of activation is strictly additive, but for the rest the measured rate constants are greater than those calculated on the assumption of additivity. The results are rationalized in terms of the positions of the transition states on the reaction coordinate. In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4Safety of 3,4-Dibromoaniline).
3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Safety of 3,4-Dibromoaniline
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary