Inhibition of tyrosine phenol-lyase by tyrosine homologues was written by Do, Quang;Nguyen, Giang T.;Phillips, Robert S.. And the article was included in Amino Acids in 2016.Formula: C9H11BrO This article mentions the following:
The authors designed, synthesized, and evaluated tyrosine homologs and their O-Me derivatives as potential inhibitors for tyrosine phenol-lyase (TPL; EC 4.1.99.2). Recently, the authors reported that homologs of tryptophan were potent inhibitors of tryptophan indole-lyase (tryptophanase; TIL, EC 4.1.99.1), with Ki values in the low micromolar range. As the structure and mechanism for TPL is very similar to that of TIL, the authors postulated that tyrosine homologs could also be potent inhibitors of TPL. However, the authors found that homotyrosine, bishomotyrosine, and their corresponding O-Me derivatives were competitive inhibitors of TPL, which exhibited Ki values in the range of 0.8-1.5 mM. Thus, these compounds were not potent inhibitors, but instead bound with affinities similar to common amino acids, such as phenylalanine or methionine. Pre-steady-state kinetic data were very similar for all compounds tested and demonstrated the formation of an equilibrating mixture of aldimine and quinonoid intermediates upon binding. Interestingly, the authors also observed a blue-shift for the absorbance peak of external aldimine complexes of all tyrosine homologs, suggesting possible strain at the active site due to accommodating the elongated side-chains. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Formula: C9H11BrO).
1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Formula: C9H11BrO
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary