5-Amidinoindoles as dual inhibitors of coagulation factors IXa and Xa was written by Batt, Douglas G.;Qiao, Jennifer X.;Modi, Dilip P.;Houghton, Gregory C.;Pierson, Deborah A.;Rossi, Karen A.;Luettgen, Joseph M.;Knabb, Robert M.;Jadhav, P. K.;Wexler, Ruth R.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2004.Application of 6515-58-8 This article mentions the following:
Structural features of the 5-amidinoindole inhibitor I of factor Xa, which displayed modest inhibition of factor IXa were varied to increase potency and improve selectivity for factor IXa. Several analogs of I with greatly diminished factor Xa selectivity were prepared and the structural features favorable for factor IXa activity were identified. In the experiment, the researchers used many compounds, for example, 3-(Bromomethyl)benzoic acid (cas: 6515-58-8Application of 6515-58-8).
3-(Bromomethyl)benzoic acid (cas: 6515-58-8) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Application of 6515-58-8
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary