Transition-Metal-Free Synthesis of Unsymmetrical Disulfides via Three-Component Reaction of Thiosulfonates, Thiourea and Alkyl halides was written by Wang, Dungai;He, Quan;Shi, Keqiang;Xiong, Mingteng;Zhou, Yifeng;Pan, Yuanjiang. And the article was included in Advanced Synthesis & Catalysis in 2021.Electric Literature of C9H11Br This article mentions the following:
A transition-metal-free approach to synthesize unsym. disulfides RSSR1 [R = (4-methoxyphenyl)methyl, (1-[(tert-butoxy)carbonyl]piperidin-4-yl)methyl, quinolin-8-ylmethyl, etc.; R1 = Bu, quinolin-8-ylmethyl, (2-oxo-1,2-dihydroquinolin-4-yl)methyl, etc.] is reported that relies on a K2CO3-promoted one-pot reaction of thiosulfonates RSS(O)2C6H4(4-CH3), thiourea and alkyl halides R1X (X = Br, Cl, I, OTs) under mild conditions. The protocol tolerates a wide range of substrates, leading to various types of unsym. disulfides in moderate to excellent yields. More importantly, the late-stage modification of natural products and drug mols. was also achieved. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7Electric Literature of C9H11Br).
2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Electric Literature of C9H11Br
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary