Synthesis of topostins B567 and D654 (WB-3559D, flavolipin), DNA topoisomerase I inhibitors of bacterial origin was written by Shioiri, Takayuki;Terao, Yoshihiro;Irako, Naoko;Aoyama, Toyohiko. And the article was included in Tetrahedron in 1998.Application In Synthesis of Isopentyltriphenylphosphonium bromide This article mentions the following:
Topostins B567 and D654 (WB-3559D, flavolipin) have been efficiently synthesized from 1,10-decanediol in 11 and 13 steps, resp., involving an asym. hydrogenation of the β-keto ester Me2CH(CH2)11COCH2CO2Et using (R)-BINAP ruthenium bromide and a peptide coupling using di-Et phosphorocyanidate (DEPC, (EtO)2P(O)CN) as key steps. In the experiment, the researchers used many compounds, for example, Isopentyltriphenylphosphonium bromide (cas: 28322-40-9Application In Synthesis of Isopentyltriphenylphosphonium bromide).
Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbonbromine bond is electrophilic in nature. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Application In Synthesis of Isopentyltriphenylphosphonium bromide
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary