Synthesis and study of anti-proliferative effect of new series of 1H-imidazo[4,5-c]quinoline derivatives in MCF-7 (human breast cancer) cells was written by Senthilkumar, Natarajan;Ravichandran, Yesudass Dominic. And the article was included in Journal of the Indian Chemical Society in 2015.Related Products of 143945-65-7 This article mentions the following:
New series of 2-(4-(7-fluoro-8-aryl-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)acetonitrile derivatives I (R = Ph, 4-IC6H4) of biol. interest have been synthesized from com. available 2-amino-5-bromo-4-fluorobenzoic acid with good yield (70%). The synthesized compounds were also screened for anti-proliferative effect on MCF-7 (human breast cancer cell line). Among them compound I (R = Ph) showed moderate inhibition compared to control. Mol. docking studies of the synthesized compounds was done on estrogen receptor (PDB: 3ERT). In the experiment, the researchers used many compounds, for example, 2-Amino-5-bromo-4-fluorobenzoic acid (cas: 143945-65-7Related Products of 143945-65-7).
2-Amino-5-bromo-4-fluorobenzoic acid (cas: 143945-65-7) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Related Products of 143945-65-7
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary