Nasli Esfahani, Anita et al. published their research in Molecular Diversity in 2022 | CAS: 128-08-5

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Category: bromides-buliding-blocks

Design and synthesis of phenoxymethybenzoimidazole incorporating different aryl thiazole-triazole acetamide derivatives as α-glycosidase inhibitors was written by Nasli Esfahani, Anita;Iraji, Aida;Alamir, Amir;Moradi, Shahram;Asgari, Mohammad Sadegh;Hosseini, Samanesadat;Mojtabavi, Somayeh;Nasli-Esfahani, Ensieh;Faramarzi, Mohammad Ali;Bandarian, Fatemeh;Larijani, Bagher;Hamedifar, Haleh;Hajimiri, Mir Hamed;Mahdavi, Mohammad. And the article was included in Molecular Diversity in 2022.Category: bromides-buliding-blocks This article mentions the following:

A novel series of phenoxymethybenzimidazole derivatives I (R1 = H, 4-F, 4-Br, 4-CH3, 3-OCH3, 4-OCH3; R2 = H, CH3; R3 = H, OCH3) were rationally designed, synthesized, and evaluated for their α-glycosidase inhibitory activity. All tested compounds displayed promising α-glycosidase inhibitory potential with IC50 values in the range of 6.31 to 49.89μM compared to standard drug acarbose (IC50 = 750.0 ± 10.0μM). Enzyme kinetic studies on I (R1 = 4-Br, R2 = R3 = H; R1 = R2 = H, R3 = OCH3; R1 = 4-CH3, R2 = CH3, R3 = H) as the most potent compounds revealed that these compounds were uncompetitive inhibitors into α-glycosidase. Docking studies confirmed the important role of benzimidazole and triazole rings of the synthesized compounds I to fit properly into the α-glycosidase active site. This study showed that this scaffold can be considered as a highly potent α-glycosidase inhibitor. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Category: bromides-buliding-blocks).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary