Synthesis and structure activity relationship of 1,3-benzo-thiazine-2-thiones as selective HDAC8 inhibitors was written by Wolff, Benjamin;Jaensch, Niklas;Sugiarto, Wisely Oki;Fruehschulz, Stefan;Lang, Maraike;Altintas, Rabia;Oehme, Ina;Meyer-Almes, Franz-Josef. And the article was included in European Journal of Medicinal Chemistry in 2019.Recommanded Product: 85118-24-7 This article mentions the following:
Here, the synthesis of 2,3-dihydroimidazo[1,2-c][1,3]benzothiazine-5-thiones I [R1 = H, Me, Br, etc.; R2 = H, Br, I, etc.; R3 = H, Me, Cl, etc.; R4 = H, Me, Cl, F; n = 0] and 3,4-dihydro-2H-pyrimido[1,2-c][1,3]benzothiazine-6-thiones I [n = 1] was described that demonstrated great selectivity for HDAC8 and chem. stability in the presence of GSH. The compounds were characterized with respect to structure-activity relationship, binding mode and target engagement in neuroblastoma cells by combining biochem. and biophys. methods with chemoinformatics. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7Recommanded Product: 85118-24-7).
2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Recommanded Product: 85118-24-7
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary