Using boronolectin in MALDI-MS imaging for the histological analysis of cancer tissue expressing the sialyl Lewis X antigen was written by Dai, Chaofeng;Cazares, Lisa H.;Wang, Lifang;Chu, Yong;Wang, Siming L.;Troyer, Dean A.;Semmes, O. John;Drake, Richard R.;Wang, Binghe. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2011.Synthetic Route of C12H16BBrO2 This article mentions the following:
Certain carbohydrate-based biomarkers are known to correlate with cancer formation and progression. By targeting sialyl Lewis X, the authors have developed the first boronolectin-MS tag conjugate, which allows for MALDI-based imaging of cancer based on its cell surface carbohydrate. In the experiment, the researchers used many compounds, for example, 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 166821-88-1Synthetic Route of C12H16BBrO2).
2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 166821-88-1) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Synthetic Route of C12H16BBrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary