Peptidomimetic inhibitors of renin incorporating topographically modified isosteres spanning the P1(→P3)-P1 sites was written by Plummer, Mark;Hamby, James M.;Hingorani, Gary;Batley, Brian L.;Rapundalo, Stephen T.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 1993.COA of Formula: C23H26BrP This article mentions the following:
Cleardihydroxyethylene isostere-modified dipeptides I (R = Ph, Δ form; R = Ph, 1-naphthyl, cyclohexane form) and II (R1 = Cl, H, R2 = isobutyl; R1 = H,. R2 = Ph) incorporating topog. modified P1(→P3) side chains were prepared and investigated as structurally novel renin inhibitors. The binding affinities of peptides containing the above dihydroxyethylene isosteres exhibited near nanomolar affinities. In the experiment, the researchers used many compounds, for example, Isopentyltriphenylphosphonium bromide (cas: 28322-40-9COA of Formula: C23H26BrP).
Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.COA of Formula: C23H26BrP
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary