Homo- and hetero-dimers of inactive organophosphorus group binding at dual sites of AChE was written by Zhao, Qian-Fei;Xie, Ru-Liang;Zhang, Tao;Fang, Jing;Mei, Xiang-Dong;Ning, Jun;Tang, Yun. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Quality Control of N-(5-Bromopentyl)phthalimide This article mentions the following:
Homo- and hetero-dimers of inactive organophosphorus group(s) dramatically enhanced the acetylcholinesterase (AChE; EC 3.1.1.7) inhibiting potency, with the highest potency observed at a tether length of 6 methylene groups (I) for the homodimers, and 7 methylene groups (II) for the heterodimers. The docking model of Drosophila melanogaster AChE suggested that I and II bound at the catalytic and peripheral sites of AChE, in which two organophosphorous groups of I individually oriented towards TRP83 of catalytic sites and TRP321 of peripheral sites, and phthalicimide group of II was appropriately arranged for a π-π interaction with the Ph ring of TYR330, furthermore, the organophosphorus group introduced hydrophobic interaction with TRP83. The compounds prepared in this work demonstrated high insecticidal activity to Lipaphis erysimi and Tetranychus cinnabarinus at the concentration 300 mg/L. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Quality Control of N-(5-Bromopentyl)phthalimide).
N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Quality Control of N-(5-Bromopentyl)phthalimide
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary