Deoxofluorination of (Hetero)aromatic Acids was written by Trofymchuk, Serhii;Bugera, Maksym Ya.;Klipkov, Anton A.;Razhyk, Bohdan;Semenov, Sergey;Tarasenko, Karen;Starova, Viktoriia S.;Zaporozhets, Olga A.;Tananaiko, Oksana Yu.;Alekseenko, Anatoliy N.;Pustovit, Yurii;Kiriakov, Oleksandr;Gerus, Igor I.;Tolmachev, Andrei A.;Mykhailiuk, Pavel K.. And the article was included in Journal of Organic Chemistry in 2020.Reference of 29241-66-5 This article mentions the following:
Diverse trifluoromethyl-substituted compounds were synthesized by deoxofluorination of cinnamic and (hetero)aromatic carboxylic acids with sulfur tetrafluoride. The obtained products were used as starting materials in the preparation of novel fluorinated amino acids, anilines, and aliphatic amines – valuable building blocks for medicinal chem. and agrochem. Of note, sulfur tetrafluoride (SF4) and hydrogen fluoride (HF) are toxic, therefore, safety and addnl. tech. training must be taken before working with them. In the experiment, the researchers used many compounds, for example, 5-Bromo-2-fluoronicotinic acid (cas: 29241-66-5Reference of 29241-66-5).
5-Bromo-2-fluoronicotinic acid (cas: 29241-66-5) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Reference of 29241-66-5
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary